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> Cerebellar Abiotrophy (ca), Post your test results here
KGH
post Feb 21 2009, 04:33 PM
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Cerebellar abiotrophy (CA) also referred to as cerebellar cortical abiotrophy (CCA) is a genetic neurological disease in animals best known to affect certain breeds of horses and dogs. It has been observed in Arabians and their derivatives, the Miniature Horse, the Gotland Pony, and possibly the Oldenberg. Aslo seen in Siamese Cats; in Angus, Polled Hereford, Charlois and Holstein Friesian cattle; Merino and Wiltshire sheep; and Yorkshire pigs. There is no cure.

It develops when neurons known as Purkinje cells in the cerebellum of the brain begin to die off. These cells affect balance, coordination, and fine-tuned movements. They have a critical role to play in the brain. The Purkinje layer allows communication between the cortical layers in the cerebellum. Put simply, without Purkinje cells, an animal loses its sense of space and distance, making balance and coordination difficult. In most cases, the neurons begin to die off shortly after the animal is born within the first 90 days post-partum. The condition is usually noticable when the foal is less than six months old, though sometimes the onset of symptoms is gradual and the foal is much older before the owner or caretaker notices a problem. Most cases are noticed either at weaning if stressful or when the youngster is brought up for handling and further training.

Cerebellar abiotrophy in horses was originally thought to be a form of cerebellar hypoplasia and was described as such in older research literature. There are diseases that cause other types of cerebellar degeneration, but the loss of Purkinje cells is a clear way to diagnose CA, and the combination of clinical signs is sufficiently unique that CA is unlikely to be confused with other conditions.

CLINICAL SIGNS (Symptoms):
Ataxia or lack of balance, an awkward wide-legged stance in the forehand with hocks close together, a palsey-like head tremor (intention tremor), hyperreactivity, lack of menace reflex (third eye lid has retarded blink or none at all), stiff or high-stepping gait shooting from the shoulder in the forehand, coarse or jerky head bob when in motion (or in very young animals, when attempting to nurse), apparent lack of awareness of where the feet are (sometimes standing or trying to walk with a foot knuckled over), poor depth perception, and a general inability to determine space and distance.

Affected horses are accident prone, tend to run into solid objects, fall to the side if rearing up and often bang their heads causing many owners ( and vets) to think that a severe head injury is the cause of the ataxia. The affected horse has normal intelligence, clear vison, good appetite and no atrophy or muscle waste.

In horses, CA is inherited as a monogenic autosomal recessive gene. This means it is not sex-linked, and the gene has to be carried by both parents in order for an affected animal to be born. Horses that only carry one copy of the gene may pass it on to their offspring, but themselves are perfectly healthy--without any clinical signs of the disorder.


University of California, Davis, USA: (Pre-testing available)
http://www.vgl.ucdavis.edu/services/horse.php

This article has been written for sE.com by Elizabeth Goodwin-Campiglio. To see more articles also written by this author/researcher see:
- http://www.waho.org/History/GeneticResearch.html
- http://en.wikipedia.org/wiki/Cerebellar_abiotrophy In collaboration with Brenda Wahler.
- Cerebellar Abiotrophy (CA): A Review at
http://www.arabianhorses.org/education/genetic/default.asp in collabration with Brenda Wahler and reviewed by current researchers as stated on the document.
- Cerebellar Abiotrophy and the Horse Genome Project at
http://www.arabianhorses.org/education/genetic/default.asp written by Elizabeth Goodwin-Campiglio and reviewed by Mesrs. Drs. Gerber and Leeb.


Please post only your test results here.



Submited to StraightEgyptians.com by Lisa Goodwin-Campiglio
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rylolin
post Mar 23 2011, 04:10 AM
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Nile Monietta (Rasmoniet RSI x Leahs Cameo by Shamruk) CA N/N

Also by parentage, Bint Monietta (SH Gazhal by Simeon Shai x Nile Monietta) CA N/N

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Posts in this topic
- KGH   Cerebellar Abiotrophy (ca)   Feb 21 2009, 04:33 PM
- - Verena1   Shaklan Ibn Bengali (FS Bengali x LM Sadunga by El...   Feb 21 2009, 04:50 PM
- - szedlisa   NOTE: UPDATE as of 25 Feb 2009: The Swiss research...   Feb 23 2009, 03:10 PM
- - Emma Maxwell   Emma Maxwell ADAWY 2000 Borneo - Ashiqa cur...   Feb 25 2009, 08:25 AM
- - Topi   SC Dacaro (Davidoff x Verbala) - N/N - Clear. -To...   Mar 9 2009, 07:24 AM
- - CAFRA Arabians   Navodchik (Drug x Nutria) - N/N - clear Barbara S...   Mar 27 2009, 06:37 PM
- - szedlisa   Testing for the CA Markers is now available in Eur...   Apr 14 2009, 02:55 PM
- - Popitka   Thank you very much Lisa, this are really good new...   Apr 14 2009, 03:28 PM
- - szedlisa   Correspondence with Dr. Penedo about this Testing ...   Apr 14 2009, 03:55 PM
- - szedlisa   Please take the AHA Survey on genetic disorders - ...   Jun 17 2009, 12:12 PM
- - szedlisa   Hopefully this thread will again be pinned as now ...   Sep 19 2009, 11:43 PM
|- - Arabian Stud Europe   QUOTE (szedlisa @ Sep 20 2009, 01:43 AM) ...   Sep 20 2009, 11:06 AM
- - Billy   BS Enrico by WH Justrice x Energia. CA Carrier   Sep 20 2009, 09:46 PM
- - dalcrista   Shahin El Nefous DF (Flambe Shahin EM x Nadeia) ...   Sep 27 2009, 08:58 PM
- - Emancy   Marcsohn EGB (QR Marc x AD Magnums Jewel) CA - Cl...   Oct 6 2009, 05:57 AM
- - Greg Egan   HI We had our stallions tested Simeon Safsal (as...   Oct 6 2009, 06:11 AM
- - CAFRA Arabians   Jenisseij (WH Justice x Medusa by Narym) CA clear ...   Oct 6 2009, 07:40 AM
|- - Popitka   QUOTE (CAFRA Arabians @ Oct 6 2009, 07:40...   Oct 6 2009, 08:42 AM
|- - CAFRA Arabians   ZITAT(Popitka @ Oct 6 2009, 10:42 AM) sup...   Oct 6 2009, 09:07 AM
- - littlearabians   Little Arabians TU Champion (Beduin x Chopiniana)...   Oct 8 2009, 06:00 PM
- - gsarrow   Kodos to all that are testing for CA and posting r...   Oct 12 2009, 02:01 AM
- - Blossom   We got our result today and we are so pleased to a...   Oct 13 2009, 10:12 AM
- - Ellerhof Arabians   New Test results: ESUNA, 2004 grey mare (Espano ...   Oct 18 2009, 08:37 PM
- - davidson   We also had our stallions tested: PA Nafal Ibn S...   Oct 29 2009, 12:40 PM
- - Charaway Arabians   Our stallion's results came back - Taralea J...   Oct 31 2009, 12:18 AM
|- - Sigrid   Hat's off for Forelock's Arabians in Holla...   Oct 31 2009, 05:22 PM
|- - bambino   QUOTE (Sigrid @ Nov 1 2009, 04:22 AM) Hat...   Nov 1 2009, 12:43 AM
|- - Sigrid   QUOTE (bambino @ Nov 1 2009, 01:43 AM) Do...   Nov 1 2009, 08:53 AM
- - Silvia Naumann   Serenity Shaham - (AK Shah Munifeh/Hamamii), geb....   Nov 17 2009, 08:50 AM
- - CAFRA Arabians   Menina (Menes x Nascha) *1990 SCID & CA frei/c...   Nov 23 2009, 01:45 PM
- - JacqueB   Hanna's Fanci (Alixir x Marah Al Magidaa by Th...   Nov 23 2009, 05:22 PM
- - Cautzar   Sawana Nile Pasha (Ansata Nile Pasha x Sawannah) N...   Nov 25 2009, 11:23 PM
- - vical   Kie-al Arabians El Seid Al Saba (Thaqib Al Nasser...   Nov 28 2009, 07:04 AM
- - frello   Wisdoms Al Ashab (Wisdom El Masran x Samarrah) N/N...   Dec 12 2009, 11:24 AM
- - Gideon Reisel   Tested via van Haeringen Lab in the Netherlands ou...   Dec 16 2009, 11:06 AM
- - Laya   Gestüt Greifenstein Stallions: EXCALIBUR (Psyner...   Dec 16 2009, 11:28 AM
|- - Mattsson   A Swedish breeder, Maria Rendahl at Kullatorp Arab...   Dec 21 2009, 07:28 PM
- - NAPHIS ARABIANS   We have tested all our horses and we have the firs...   Dec 22 2009, 08:03 AM
- - linda   We have tested three of our mares, Spring Kantata...   Dec 22 2009, 06:18 PM
|- - Malicia   OM EL JAZMINA (Sanadik El Shaklan * Om El Jazira b...   Dec 22 2009, 06:41 PM
- - FAArabians   EL NINJO: (Emiliusz x Claudiaa v. Psytadel) CA N/N...   Dec 22 2009, 09:18 PM
- - Popitka   We are happy to announce the results: CEREBELLAR ...   Dec 23 2009, 08:59 AM
|- - NAPHIS ARABIANS   ZITAT(Popitka @ Dec 23 2009, 09:59 AM) We...   Dec 23 2009, 09:15 AM
|- - Popitka   QUOTE (NAPHIS ARABIANS @ Dec 23 2009, 10...   Dec 23 2009, 09:23 AM
- - kal   sorry guys not results but ive emailed vhl to get ...   Dec 23 2009, 09:38 PM
|- - cookie   Hi, just been on vhl site,and all seems to be work...   Dec 24 2009, 11:28 PM
- - kal   got paper work but cant read it see help   Dec 24 2009, 11:49 PM
- - Gideon Reisel   A new website is constructed to allow plenty of da...   Dec 31 2009, 11:07 AM
- - CAFRA Arabians   ZITAT(Popitka @ Dec 23 2009, 10:59 AM) We...   Jan 2 2010, 10:06 AM
|- - Popitka   QUOTE (CAFRA Arabians @ Jan 2 2010, 11:06...   Jan 8 2010, 02:38 PM
- - Carradale Arabians   MONESCOCIA (Ajman Moniscione x Estonia) - CA CLEAR...   Jan 12 2010, 02:10 PM
- - silver 2006   NEBRAS AL RAYYAN CA Clear und SCID Clear   Feb 1 2010, 11:31 AM
- - gsarrow   See http://www.cerebellar-abiotrophy.org/ to ad...   Feb 2 2010, 06:52 AM
- - silver 2006   TEYMUR B (ASSAD / 214 IBN GALAL I) CA Clear (...   Feb 2 2010, 04:15 PM
- - iArabians   TW Bengali Bey(FS Bengali x TW A Melody) CA and SC...   Feb 3 2010, 02:10 AM
- - Al-Zawraa Arabians   C. Aziza (Ansata Sinan x C. Samila by Malik AA) CA...   Feb 4 2010, 10:30 AM
- - pathannay   AZIZA (Arastin x Sadika) CA CLEAR   Feb 4 2010, 11:52 AM
- - kal   ATIYAH ca clear scid clear   Feb 5 2010, 01:13 PM
- - cookie   PIANIST (Gazal al shaqab x HS Pelagrina ) CA Cle...   Feb 17 2010, 12:57 AM
- - stutteri svanemosen   Wth permission from Murana Stud : Dubai Pasha ( B...   Feb 17 2010, 04:03 PM
- - sheikhrissan   am most happy to report that the full set of resul...   Feb 17 2010, 05:47 PM
- - Abbasiyah   Bassel Al Rayyan (Ashhal Al Rayyan x Dana Al Rayya...   Feb 27 2010, 12:51 AM
- - iArabians   Congrats! TW Bengali Bey(*FS Bengali x TW A Me...   Feb 27 2010, 08:09 PM
- - smj   Hiya We're pleased to annouce that your SE...   Mar 4 2010, 12:20 PM
- - Eline   Results of Anais el Arab, Belgium testes via UC D...   Mar 13 2010, 09:22 AM
- - szedlisa   There have been some changes at the CA website ww...   Mar 15 2010, 12:39 PM
- - velika-arabians   Dear Members, KAS Von Dutch (Kubinec x Vypiska) i...   Mar 19 2010, 11:16 AM
|- - Nicolas Jamar   QUOTE (velika-arabians @ Mar 19 2010, 12...   Sep 6 2010, 12:28 PM
- - diefreddies   Ahlams Delaila ( U.P. Mohamed Pasha x Il bint Ahla...   Mar 20 2010, 02:29 PM
- - hemo   QUOTE (KGH @ Feb 21 2009, 04:33 PM) Cereb...   Apr 2 2010, 06:24 PM
- - tchaata   I am always quite surprised as not so many N/CA te...   Apr 3 2010, 02:35 PM
- - szedlisa   http://www.laboklin.co.uk/laboklin/showGen...?test...   Apr 9 2010, 03:22 PM
- - Gabriele Schweiher   Shanah Halim, *1996, Dalia Halim x U.P. Shari CA ...   Apr 15 2010, 05:56 AM
- - SE Legacy   SEL Marzuq - 2007 Bay SE Stallion (Alfano Mystall...   Apr 16 2010, 02:45 AM
- - szedlisa   Now on the heels of the Swiss Registry accepting c...   Apr 18 2010, 03:11 AM
- - szedlisa   Working in conjuction with and under the same lice...   Apr 20 2010, 11:49 PM
- - jsimicek@msn.com   Asami Ruuh ( Hadaya el Tareef x Noble Imdalia) 199...   Apr 28 2010, 02:51 AM
- - lma   QAMAR EL DINE (Maysoun x Raqqisa) CA and SCID C...   May 6 2010, 08:16 PM
- - almuntaha   These Horses of Al Muntaha Arabians are already te...   Jun 1 2010, 10:44 AM
|- - Mandarin   ZITAT(almuntaha @ Jun 1 2010, 12:44 PM) T...   Jun 1 2010, 01:12 PM
|- - Gudrun Irtzing   Hengste: VDA Habib (DF Malik Jamil x Hananda) N/N ...   Aug 6 2010, 02:31 PM
- - dgfour   I am happy to report that Kamal Ibn Adeed was test...   Sep 12 2010, 07:45 PM
- - beavercreek   GR Maatin, Lahbat Nejm, and BC Warda have tested C...   Oct 21 2010, 02:47 AM
- - Eline   Athina el Jamaal (Maysoun x Athenais el Jamaal) --...   Oct 21 2010, 01:51 PM
- - rylolin   SH Gazhal (Simeon Shai x Bint Nessma by Shamruk) h...   Oct 22 2010, 03:20 PM
- - szedlisa   The latest statistics are in This week we rec...   Oct 23 2010, 03:43 PM
|- - Dr Daniel Wigger   Lulua Jamil (NK Hafid Jamil x PA Shubani Il Nasek)...   Dec 8 2010, 02:05 PM
|- - Gabriele Schweiher   ZITAT(Dr Daniel Wigger @ Dec 8 2010, 03:0...   Dec 8 2010, 02:22 PM
- - szedlisa   VERY IMPORTANT updates have been made by Dr. Cecil...   Jan 7 2011, 12:12 PM
|- - phanilah   The Cerebellar Abiotrophy (CA) Project Update from...   Jan 13 2011, 06:57 PM
- - Emancy   CHAMIN E (El Amin x Marih Loretta by Nazdrowie) N...   Jan 23 2011, 05:15 PM
- - Ursula   Ibn Shah http://www.allbreedpedigree.com/ibn+shah...   Mar 8 2011, 08:21 AM
|- - Gudrun Irtzing   ZITAT(Ursula @ Mar 8 2011, 09:21 AM) Ib...   Mar 8 2011, 08:42 AM
- - Ursula   Danke Gudrun hatte mich auch sofort in ihn verlieb...   Mar 8 2011, 08:55 AM
- - szedlisa   GREAT NEWS: The laboratory of the Netherlands @ D...   Mar 12 2011, 04:46 PM
|- - jillerisman   QUOTE (szedlisa @ Mar 12 2011, 05:46 PM) ...   Mar 21 2011, 08:36 PM
- - silver 2006   RIAD HABANA (Teymur B /Habenda) Ca N/N   Mar 22 2011, 08:47 PM
- - Langsted   Estampa (Gaspar x Echidna (Elandra x Ararat)) CA ...   Apr 12 2011, 08:25 AM
- - silver 2006   Riad Habana (Teymur B/Habenda) CA N/N   Apr 12 2011, 01:10 PM
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